Our results linking RAD52 higher gene expression to UADT and LUSC, along with our recent observation that a rare truncating BRCA2 genetic variant, rs11571833 (K3326X) is associated with a 2.5 fold risk of squamous cell carcinomas of the lung and UADT [38,39], suggests that such targeted therapy approaches may be worth investigating in UADT and LUSC tumors. This evidence concerns the gene BRCA2 and squamous cell lung carcinoma.