More recently, Hogg et al. [39] did not find significant relationship between birth weight and HSD11B2 promoter DNA methylation across normal birth weight ranges and in IUGR cases, suggesting that this issue is still under debate and results are probably highly dependent on the location of the CpG sites of the HSD11B2 promoter in which the methylation analyses are conducted. The gene discussed is HSD11B2; the disease is fetal growth restriction.