We assessed gliosis across a number of clinically relevant murine models of inherited retinal disease that represent a range of degeneration rates: three models of retinitis pigmentosa (RP) (Prph2+/Δ307, Rho-/-, Pde6brd1/rd1) and a model of Leber Congenital Amaurosis (LCA) (Crb1rd8/rd8). Here, PDE6B is linked to Leber congenital amaurosis.