Furthermore, infection with BCG::RD1 – a recombinant strain of BCG containing the RD1 locus, the absence of which accounts, to a large extent, for the attenuation of BCG [66] – significantly increased the induction of miR-132-3p and miR-212-3p, with respect to BCG, attaining a level that was not significantly different from cells infected with the virulent strains (Fig. 2C,D and S6 Table). Here, PDE6B is linked to infection.