CDH17 and early-onset autosomal dominant Alzheimer disease: Moreover, pathway analysis revealed that these genes were significantly enriched in several signaling pathways with the hepermethylated genes in Cadherin signaling (p = 1.54 × 10-7) and Wnt signaling pathways (p = 2.19 × 10-7); while the hypomethylated genes were enriched in Alzheimer disease-presenilin (p = 1.08 × 10-4) and Cadherin signaling pathways (p = 2.67 × 10-3) (Table 3).