The APOB insertion/deletion (ins/del) polymorphism (rs17240441), which produces a difference of three amino acids in the signal peptide, has been associated with fasting total cholesterol (TC) [2,3], TAG [4,5], high density lipoprotein-cholesterol (HDL-C) [2] and low density lipoprotein-cholesterol (LDL-C) [2,3] concentrations, along with cardiovascular disease-related outcomes [6-11]. Here, APOB is linked to cardiovascular disorder.