Since several serious neural system disorders including dementia and AD in the elderly are mainly caused by cerebral amyloid angiopathy (CAA) via reduction of blood flow [29], ApoE in lipidation state may contribute to critical impact on Aβ fibril formation [30] and finally result in neural inflammatory responses such as synaptic dysfunction, neuronal death, and neurodegeneration. Here, APOE is linked to cerebral amyloid angiopathy.