CD44 and neoplasm: Indeed, our data indicated that human EOC patients’ tumor tissues and SKOV3 CD117+CD44+ CSCs had significantly high expressions of HOTAIR compared with the SKOV3 tumor tissues and SKOV3 non-CD117+CD44+CSCs, and that the down-regulated HOTAIR expression in CD117+CD44+-shHOTAIR markedly reduced cellular metastasis and invation in vitro as well as the tumorgeniesis in mice.