PPP2R2C and central nervous system cancer: Overexpression of B55gamma in U251 Glioma cells significantly increased the cell viability in response to glucose depletion in multiple time points compared with U251 control cells, while knocking down of B55gamma in NHA cells rendered cells sensitive to glucose depletion (Figure 2A & 2B), suggesting B55gamma participated in the regulation of cell apoptosis pathway in response to glucose starvation.