AQP4 and neuromyelitis optica: More importantly, AQP4-specific recombinant Abs (rAbs) derived from these CSF plasmablasts, when administered in experimental animals, recapitulated the myriad pathological features of NMO lesions that include perivascular loss of astrocytes, terminal complement activation, granulocyte infiltration, and subsequent oligodendrocyte cell death and myelinolysis (3, –, 5).