Oxidative stress is a central feature of ALS (43) and stress granule markers have been found to co-localize with FUS-positive and TDP-43-positive inclusions in the spinal cord of ALS patients (32,34,44), suggesting long-term oxidative stress is associated with pathological inclusions of FUS and TDP-43 in both fALS and sALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.