However, a significant fraction of transplanted patients lacks a suitable HLA-matched donor, and patients with a lower degree of chimerism, both in the lymphoid and myeloid compartments, show an incomplete reconstitution of lymphocyte counts and a high incidence of autoimmunity.8,9 For these reasons, administration of WAS gene–corrected autologous hematopoietic stem cells (HSCs) could represent a valid alternative therapeutic approach, as demonstrated for other primary immunodeficiencies.10 Here, WAS is linked to Autoimmunity.