Furthermore, VAV3 overexpression and knockdown exhibited stimulatory and inhibitory effects on the levels of phosphor-PI3K, phosphor-AKT, cyclin A, cyclin B, and CDK1 in FHC cells and DLD-1 cells, respectively (Supplementary Fig, S2c). The gene discussed is AKT1; the disease is hypercholesterolemia, familial, 1.