Regarding the metabolic co-activators PGC1α and PGC1β (encoded bythe PPAGC1A and PPARGC1B genes, respectively), PPARGC1Aexpression was significantly increased in ODIII and GL tumors, whereasPPARGC1B expression was robustly decreased in all gliomas. The gene discussed is PPARGC1B; the disease is central nervous system cancer.