Along the same line, glioma samples (ODsand GL) with high HDAC4 and SIRT1 expression were metabolomicallydifferent from samples with low HDAC4 and SIRT1 expression, thelatter having a significantly lower GPChol/PChol ratio than the former group(Figure 6C and 6D, respectively). The gene discussed is SIRT1; the disease is central nervous system cancer.