The whole-transcriptome sequencing analysis uncovered enhanced expression of CASP3 and DIABLO, whereas XIAP was decreased in DMD iPSC-CMs (Fig. 3A,B), implying a possible role of mitochondria (Verhagen et al., 2000) in mediating apoptosis of DMD iPSC-CMs. Here, CASP3 is linked to Duchenne muscular dystrophy.