HAVCR2 and experimental autoimmune encephalomyelitis: For example, blocking of TIM-3 has been shown to improve the effector function of exhausted T cells in chronic viral infections and tumours12, 15, 16, 17, whereas enhancement of TIM-3 signalling appears to ameliorate Th-1-mediated experimental autoimmune encephalomyelitis (EAE)6, 18, 19.