Similar to the previous data in cerebella of our SCA2 mouse model, a significant decrease of FBXW8 in the RIPA-soluble fraction to about half (-1.67-fold, p-value 0.0235) of control levels was observed, while a significantly increased abundance to doubled levels (+2.04-fold, p-value 0.0283) was found in the SDS-soluble fraction (4 controls vs. 4 SCA2 patients) (Fig. 4C and S6 Fig.). Here, FBXW8 is linked to spinocerebellar ataxia type 2.