In this regard, phosphorylation of the death inducing signaling complex (DISC) components Fas, FADD and caspase-8, as well as the caspase-8 substrate Bid and anti-apoptotic suppressors of death receptor-induced apoptosis (c-FLIP, XIAP) has been reported in association with tumor resistance to TRAIL or Fas [20–22,25]. Here, CASP8 is linked to neoplasm.