The increased activity of NFκB in ovarian cancer cells is mediated by enzymes of the IκB kinase (IKK) complex, which phosphorylate the NFκB inhibitory protein, IκBα, resulting in IκBα proteasomal degradation and nuclear translocation of NFκB subunits [42,43,44,45]. This evidence concerns the gene NFKB1 and ovarian carcinoma.