We have recently shown that in ovarian cancer cells, the IL-8 transcription is regulated by S536-p65 NFκB, IKKβ, and EGR-1, and that proteasome inhibition developed as a strategy to inhibit NFκB-dependent transcription, paradoxically increases the IL-8 expression in ovarian cancer cells by increasing the S536-p65, IKKβ and EGR-1 recruitment to IL-8 promoter [41]. The gene discussed is IKBKB; the disease is ovarian cancer.