NFKBIA and ovarian cancer: In addition, the IL-8 transcription in ovarian cancer cells is positively regulated by the transcription factor early growth response-1 (EGR-1) binding to IL-8 promoter, and by enzymes of IKK complex that phosphorylate both IκBα, leading to its cytoplasmic degradation, and p65 NFκB, resulting in its increased transcriptional activity (Figure 4) [41,42,43,44,45].