BMP7 and glomerulosclerosis: By giving exogenous recombinant BMP-7 to DKD rats, researchers have found reduced renal fibrosis, podocyte loss, kidney injury, oxidative stress, extracellular matrix accumulation, urinary protein, and glomerular filtration rate[16,17], suggesting that exogenous administration of BMP-7 may inhibit glomerulosclerosis and interstitial fibrosis, thereby improving the renal function in DKD.