Thus, in order to gain further insights into the genetic factors that may affect treatment outcome in CHC; it is interesting to examine pretreatment expression profiles of circulating INF-related miRNAs, in particular, miR-146a, miR-34a, miR-130a, miR-19a, miR-192, miR-195, and miR-296, previously reported to be induced by INFs in different in vitro models [15,17,18,24–26]. The gene discussed is CBLIF; the disease is cryohydrocytosis.