TLR9 and systemic lupus erythematosus: It is an open question whether some disease-associated antibodies are elicited in this way; however, inhibition of TLR-9 blocked antibody production by B-cells from systemic lupus erythematosus (SLE) patients, and in one murine SLE model, B cell overexpression of TLR-7 resulted in increased production of autoantibodies to RNA/protein complexes and worsening of disease [18,19].