The frequency of IDH1 mutation was 80.8% in AGII (21 out of 26), 61.1% in AGIII (11 out of 18) and 12.8% in GBM (11 out of 86) (Fig. 1D, 1E and 1F, respectively), which was also described in our previous study of the frequency of IDH1 mutations in a series of GBM patients [23]. This evidence concerns the gene IDH1 and glioblastoma.