We also examined the relationship between p53 and Scd1 (a mouse homologue of SCD) in Kras-driven mouse pancreatic ductal adenocarcinoma (mPDA) cell lines established from KrasLSL-G12D; Pdx1-cre, or KrasLSL-G12D; P48-cre mice (KC cell lines) and KrasLSL-G12D; p53lox/+; Pdx1-cre compound mutant mice (KPΔC cell lines) [39]. This evidence concerns the gene KRAS and pancreatic ductal adenocarcinoma.