One tumour (P13) had acquired a frameshift change and another (RK133) carried a somatic SNV, p.Arg320Gly, of probable pathogenicity (SIFT=0.03 and Polyphen2=0.99) at an evolutionarily residue that is recurrently mutated in lung cancers (http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=KEAP1; http://www.cbioportal.org/public-portal/cross_cancer.do?cancer_study_id=all&data_priority=1&case_ids=&gene_set_choice=user-defined-list&gene_list=NFE2L2%0D%0AKEAP1&clinical_param_selection=null&tab_index=tab_visualize&Action=Submit#crosscancer/overview/1/NFE2L2%20KEAP1). The gene discussed is NFE2L2; the disease is neoplasm.