FH and neoplasm: Patient P11 carried the germline FH variant c.1189G>A (p.Gly397Arg) and the tumour showed copy-neutral LOH around FH. Functional prediction programmes and the FH mutation database reported this variant as likely to be pathogenic ( http://chromium.liacs.nl/lovd_sdh/variants.php?action=search_unique&select_db=FH).