ARID2 is a subunit of the PBAF chromatin-remodelling complex, has been reported as a potential driver gene in hepatocellular carcinoma24 and is functionally related to other cancer genes including ARID1A. Following independent confirmation of the SETD2, BAP1 and ARID2 mutations in our discovery phase samples using Sanger or Ion Torrent sequencing, we screened a replication set of 60 archival pRCCs for mutations in these genes (Supplementary Table 3), resulting in an additional five BAP1, three SETD2, and three ARID2 mutations. Here, SETD2 is linked to cancer.