IL—10 and other IL—6 family cytokines like LIF, OSM, IL-11 are known to be elevated in the plasma of some implant cachexia models [15,36] and though the presence of these cytokines has not been established in the ApcMin/+ mouse, there is a possibility that these could play a role in STAT-3 activation in the non—cachectic mice. This evidence concerns the gene OSM and Cachexia.