Pull-down assays in human non-small cell lung carcinoma H1299 cells engineered to overexpress p53 as well as co-immunoprecipitation experiments in Trp53+/+ MEFs revealed that p53WT, but not p53R175H and p53R273H, physically binds to SERCA, an interaction that relies on the C-terminal fragment of p53 (aa 294-393).9 This domain of p53 is known to accommodate several post-translational modifications,18 which, at least theoretically, can modulate its ability to bind (and hence regulate the activity of) SERCA. Here, TP53 is linked to non-small cell lung carcinoma.