RP1 and hepatocellular carcinoma: Downregulation of its expression promotes invasion by hepatocellular cancer cells.24 IGFBP-rP1-overexpressing cells in breast cancer show reduced migration,25 and IGFBP-rP1 is also correlated with early metastasis of CRC.26, 27 We previously demonstrated that the restoration of IGFBP-rP1 by 5-aza-dC inhibits migration and invasion in CRC cell lines.