Moreover, the abundance of IGFBP-rP1 is inversely correlated with a poor prognosis.20 In addition, when we restored the expression of IGFBP-rP1 with 5-aza-2′-deoxycytidine, the migration and invasion abilities of CRC cells decreased.21 In aggregate, although IGFBP-rP1 has been confirmed as a master regulator of cancer-cell fate, its functional role in EMT and metastasis remains largely unknown. Here, RP1 is linked to colorectal carcinoma.