The forcing expression of E-cadherin was not sufficient to restore epithelial characteristic in murine spindle carcinoma cells28 as well as failed to reverse the fibroblastic morphology of MDCK-Snail cells.29 Furthermore, reduced E-cadherin expression triggered by overexpression of Slug and Twist failed to induce full EMT and enhance metastasis in CRC cells.30 More importantly, clinical data analyses also indicated that IGFBP-rP1 is inversely associated with the classical EMT markers. This evidence concerns the gene RP1 and colorectal carcinoma.