Mounting evidence indicates that IGFBP-rP1 possesses tumor-suppressor activity in various tumor types.15, 16, 17, 18, 19 Indeed, our previous studies clearly revealed that IGFBP-rP1 inhibits cell proliferation, decreases soft agar colony formation, and induces apoptosis in CRC cell lines. Here, IGFBP7 is linked to neoplasm.