SLC1A3 and glaucoma: Moreover, previous work has shown that glutamate excitotoxicity and oxidative stress are involved in retinal damage in glaucoma.9 Furthermore, reportedly, the human GLAST ortholog excitatory amino-acid transporter 1 (EAAT1) is downregulated in the retinas of human patients with glaucoma.10 This result suggests that impairments in EAAT1 activity may be related to the pathogenesis of glaucoma.