JSI-124 (cucurbitacin I), a natural chemical compound belonging to the cucurbitacin family, was discovered as a potent STAT3 inhibitor and exhibited anticancer potential through the induction of apoptosis in a wide variety of human tumor cell lines in multiple cancer cell lines, such as breast cancer, lung cancer, glioma, and melanoma [19,21,22]. This evidence concerns the gene STAT3 and neoplasm.