Combinations of several markers were identified by MDR to be associated with increased risk of BD, including rs2071427 in NR1D1, rs4774388 in RORA, and rs3750420 and rs11144047 in RORB. In the biological loops in circadian rhymes, NR1D1, RORA, and RORB completed ROREs binding in ARNTL. Ueda et al., [36] found that the NR1D1/ROR response element play an important role in generating circadian night expression in phase with ARNTL gene expression in vitro validation of clock-controlled elements. This evidence concerns the gene CLOCK and Behcet disease.