Evidence recapitulating NASH in gp78-KO mice indicates that hepatocytes of gp78-KO are significantly enlarged and distended by large single or multiple well-defined droplets of fat, sharply different from the WT hepatocytes that have distinctly round nuclei with one or two prominent nucleoli (Fig. 2A, a). Here, AMFR is linked to metabolic dysfunction-associated steatohepatitis.