In this study, drinking EGCG significantly inhibited the development of liver cell adenomas compared to the control group (EGCG-untreated), and this was associated with reduced phosphorylation of IGF-1R, ERK, and Akt proteins in the liver, improvement of liver steatosis, and activation of AMP-activated kinase protein in the liver. The gene discussed is IGF1R; the disease is fatty liver disease.