In the model of severe infection (C3H/He), PTX therapy also ameliorated the expression of the biomarkers of heart injury Cx43 loss and FN deposition in the heart tissue, CK-MB activity levels in the serum (p<0.01, S5A Fig. and S5B Fig.) and ECG abnormalities (p<0.05, S5C Fig. and S5D Fig.). The gene discussed is FN1; the disease is infection.