Accumulating evidence supports an association between ILD and the presence of certain myositis-specific autoantibodies (MSAs); in particular, anti-aminoacyl tRNA-synthetase enzyme (ARS) antibodies and anti-melanoma differentiation-associated gene 5 (MDA-5) antibody (also termed anti-CADM-140 antibody) are more closely associated with ILD than other MSAs [10–15]. The gene discussed is IFIH1; the disease is myositis disease.