These include a search for rare variants across GDF5, a gene harboring a known susceptibility variant for osteoarthritis in 992 cases and 944 controls [18,19], a similar rare variant screen focused on TNFRSF6B in pediatric-onset IBD [12], exome sequencing of TNFAIP3 in 19 primary Sjögren’s syndrome patients with lymphoma [31], and targeted sequencing of the FAM167 and BLK exomes in 191 SLE cases and 96 controls [29]. Here, TNFAIP3 is linked to systemic lupus erythematosus.