CCN2 and ulcer disease: Figure 5(a) shows a typical cutaneous wound area profile in a patient with a neuropathic hallux plantar ulcer, with times (arrows) when ulcer fluid was collected and then analyzed the following serial debridements. The respective Western immunoblot analysis for CTGF in the ulcer fluid is shown in Figure 5(b). CTGF was detected as a predominant intact ~36–38 kDa series of molecular mass bands, typical of known intact CTGF glycoforms [24]. In some immunoblots, there was also lower molecular mass signal at ~26 kDa (Figure 5(b)) as previously observed in biological fluids [18].