The group data (n = 32 study subjects) relating ulcer healing rate to rate of change in CTGF in ulcer fluid across an average time period of 10 days showed that an increase in CTGF levels correlates highly significantly with wound healing rate, indicated as percentage reduction in ulcer area per 10 days (Figure 5(c)); r = 0.406; P < 0.001. Here, CCN2 is linked to ulcer disease.