For instance, while VEGFR-1 has no role in endothelial cell proliferation [24], VEGFR-2 plays a pivotal role in the activation of downstream components that are responsible for proliferation, including endothelial cell invasion, migration, differentiation, and embryonic angiogenesis as well as tumor angiogenesis [25, 26]. The gene discussed is FLT1; the disease is neoplasm.