SMARCA4 and cancer: Subunits of BAF complex are mutated in a variety of cancers: loss of function of the auxiliary subunit SMARCB1 was detected in 98% of rhabdoid tumors and in 30–40% of familial Schwannomatosis; the subunit PBRM1 was mutated in 41% of renal carcinoma; the subunit ARID1A was mutated in 50% of ovarian clear cell carcinoma and in 35% of endometrial carcinoma; and SMARCA4 itself was mutated in 35% of nonsmall cell lung cancers [113].