Also pathology reported an immunostain for CD138 showing increased numbers of plasma cells and clusters of plasma cells with the hematopoietic marrow, consistent with involvement by the plasma cell neoplasm, and an immunostain for cytokeratin AE1/3 was negative, excluding the possibility of metastatic carcinoma, and the presence of a plasma cell neoplasm within the marrow does not likely explain the radiographic finding of osteoblastic lesions. The gene discussed is SDC1; the disease is metastatic carcinoma.