Additionally, it is worth noting that a tight regulation of euglycemia would be more consistent with health and survival than a predilection for hypoglycemia [Tan & Flanagan, 2013], thus “improving health”, as CR has been broadly documented as doing, might mean preventing the innate endocrinological/metabolic derangements that are merely coincident with the longevity of the GHR-KO mouse. The gene discussed is GHR; the disease is Hypoglycemia.