However, in the meantime, we tested two candidate gene lists, the Simons Foundation Autism Research Initiative (SFARI) database of curated autism candidates (SFARIdb) and the recently identified rare de novo variants in autism probands (rDNV) [6], to see if a statistically significant overlap with Fmrp targets could be reproduced just using equally sized sets of random genes sampled to match as best possible the transcript abundance (Additional file 1: Figure S1) or coding sequence length (Additional file 2: Figure S2) of the Fmrp target genes. The gene discussed is FMR1; the disease is autism.