Consistent with this finding, transfection of a miR-1246 mimic into SLE B cells induced a 3.72-fold upregulation of miR-1246 expression while those of the unrelated miR-126, miR-142-3p, and miR-142-5p remained unchanged (Figure 3D) and a significantly decreased level of EBF1 protein (Figure 3E, F). This evidence concerns the gene EBF1 and systemic lupus erythematosus.