TP53 and Autoimmunity: These implicated that activation of B cells could downregulate miR-1246 expression through the AKT-P53 signaling pathway, and decreased miR-1246 could aggravate B cells’ further activation by regulating EBF1, which means downregulation of miR-1246 in B cells is not just a consequence of increased lymphocyte activity, but also a potential cause of autoimmunity.