Furthermore, AR signaling has been indicated as a key step for PCa progression (13), in which circumstance there is crosstalk with multifunctional growth factor signaling pathways, such as EGF, FGF, IGF, TGF-β and VEGF (14), as well as with the PI3K/Akt/mTOR pathway (15). This evidence concerns the gene AR and posterior cortical atrophy.