Following screening, which involved the investigation of mitochondrial oxidation consumption, the AKT and mTOR pathway and microRNAs which may target glycolysis and mitochondrial apoptosis pathways, including cytochrome c and Bcl-2, the expression of LDHA was found to be significantly decreased subsequent to CDDP treatment at varying doses in two oral cancer cell lines (P<0.05; Fig. 1A). The gene discussed is LDHA; the disease is lip and oral cavity carcinoma.