Anemia is also extremely rare in the hyaline-vascular CD, and Yang et al (8) proposed that elevated IL-6 acts on the IL-6 receptors in liver and tumor lymph node cells, resulting in the enhanced expression of hepcidin, consistent with the role of the IL-6/hepcidin pathway in anemia of chronic disease in CD (9). This evidence concerns the gene IL6 and anemia (phenotype).