However, CEP65 did not affect the mRNA expression of MMP2, indicating that the elevated MMP2 activity may be due to altered regulators upstream of MMP2. MMP2 belongs to a family of Zn2+-dependent proteolytic enzymes, which are associated with cancer cell invasion, growth, angiogenesis, inflammation and metastasis (11,15). The gene discussed is MMP2; the disease is cancer.