Although only one MM cell line was investigated in the present study, curcumin significantly upregulated p53 and Bax and downregulated the negative inhibitor for p53, MDM2. Therefore, it can be concluded that curcumin may inhibit the proliferation and induce the apoptosis of MM cells through a p53-mediated pathway different from the one identified in the study by Bharti et al (24). This evidence concerns the gene MDM2 and Miyoshi myopathy.