Curcumin inhibits the proliferation, invasion, metastasis and angiogenesis of a number of cancers through interaction with a variety of cell signaling proteins (11), the majority of which are proteasome target proteins, such as the tumor suppressor protein, p53, and the pro-apoptotic protein, B-cell lymphoma 2 (Bcl-2) associated X protein (Bax) (12,13). The gene discussed is PROS1; the disease is cancer.