The intracellular activity of the MAPK pathway involves complex interactions between the PI3K/Akt cascades, which leads to proliferative and apoptotic activities being generated via competing mechanisms (16); however, it remains unclear whether augmented phosphorylated Erk1/2 (pErk1/2) activity is a prognostic factor for the outcome of breast cancer. This evidence concerns the gene AKT1 and breast cancer.