CD82 and Familial prostate cancer: An initial study indicated that the KAI1/CD82 gene exhibited the inhibition specifically towards the metastasis of prostate cancer (17); however, later studies have revealed that the inactivation of this gene occurs in a number of other malignant tumors, including thyroid (14), breast (18–20), endometrial (16), laryngeal (21), colon (22), gastric (7,23), gallbladder (24), liver (25), kidney (26), bladder (27) and prostate (28) cancer.